RapamycinFungusV1, Main, Exploration, bibRecord, 000806

Integrated transcriptomic analysis of Trichosporon Asahii uncovers the core genes and pathways of fluconazole resistance.

Identifieur interne : 000806 ( Main/Exploration ); précédent : 000805; suivant : 000807

Integrated transcriptomic analysis of Trichosporon Asahii uncovers the core genes and pathways of fluconazole resistance.

Auteurs : Haitao Li [République populaire de Chine] ; Congmin Wang [République populaire de Chine] ; Yong Chen [États-Unis] ; Shaoqiang Zhang [République populaire de Chine] ; Rongya Yang [République populaire de Chine]

Source :

Scientific reports [ 2045-2322 ] ; 2017.

RBID : pubmed:29259317

Descripteurs français

KwdFr :
- Analyse de profil d'expression de gènes (méthodes), Antifongiques (pharmacologie), Fluconazole (pharmacologie), Oxydoréduction (effets des médicaments et des substances chimiques), Résistance des champignons aux médicaments (effets des médicaments et des substances chimiques), Résistance des champignons aux médicaments (génétique), Tests de sensibilité microbienne (MeSH), Transcriptome (effets des médicaments et des substances chimiques), Transcriptome (génétique), Trichosporon (génétique).
MESH :
- effets des médicaments et des substances chimiques : Oxydoréduction, Résistance des champignons aux médicaments, Transcriptome.
- génétique : Résistance des champignons aux médicaments, Transcriptome, Trichosporon.
- méthodes : Analyse de profil d'expression de gènes.
- pharmacologie : Antifongiques, Fluconazole.
- Tests de sensibilité microbienne.

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Drug Resistance, Fungal (drug effects), Drug Resistance, Fungal (genetics), Fluconazole (pharmacology), Gene Expression Profiling (methods), Microbial Sensitivity Tests (MeSH), Oxidation-Reduction (drug effects), Transcriptome (drug effects), Transcriptome (genetics), Trichosporon (genetics).
MESH :
- chemical , pharmacology : Antifungal Agents, Fluconazole.
- drug effects : Drug Resistance, Fungal, Oxidation-Reduction, Transcriptome.
- genetics : Drug Resistance, Fungal, Transcriptome, Trichosporon.
- methods : Gene Expression Profiling.
- Microbial Sensitivity Tests.

Abstract

Trichosporon asahii (T. asahii) has emerged as a dangerous pathogen that causes rare but life-threatening infections. Its resistance to certain antifungal agents makes it difficult to treat, especially for patients undergoing long-term antibiotic therapy. In this study, we performed a series of fluconazole (FLC) perturbation experiments for two T. asahii strains, a clinical isolate stain CBS 2479 (T2) and an environmental isolate strain CBS 8904 (T8), to uncover potential genes and pathways involved in FLC resistance. We achieved 10 transcriptomes of T2 and T8 that were based on dose and time series of FLC perturbations. Systematic comparisons of the transcriptomes revealed 32 T2 genes and 25 T8 genes that are highly sensitive to different FLC perturbations. In both T2 and T8 strains with the phenotype of FLC resistance, the processes of oxidation-reduction and transmembrane transport were detected to be significantly changed. The antifungal susceptibility testing of FLC and penicillin revealed their resistance pathways are merged. Accumulated mutations were found in 564 T2 and 225 T8 genes, including four highly mutated genes that are functionally related to the target of rapamycin complex (TOR). Our study provides abundant data towards genome-wide understanding of the molecular basis of FLC resistance in T. asahii.

DOI: 10.1038/s41598-017-18072-9
PubMed: 29259317
PubMed Central: PMC5736589

Affiliations:

République populaire de Chine, États-Unis

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000649
to stream Main, to step Curation: 000649

Le document en format XML

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<front><div type="abstract" xml:lang="en">Trichosporon asahii (T. asahii) has emerged as a dangerous pathogen that causes rare but life-threatening infections. Its resistance to certain antifungal agents makes it difficult to treat, especially for patients undergoing long-term antibiotic therapy. In this study, we performed a series of fluconazole (FLC) perturbation experiments for two T. asahii strains, a clinical isolate stain CBS 2479 (T2) and an environmental isolate strain CBS 8904 (T8), to uncover potential genes and pathways involved in FLC resistance. We achieved 10 transcriptomes of T2 and T8 that were based on dose and time series of FLC perturbations. Systematic comparisons of the transcriptomes revealed 32 T2 genes and 25 T8 genes that are highly sensitive to different FLC perturbations. In both T2 and T8 strains with the phenotype of FLC resistance, the processes of oxidation-reduction and transmembrane transport were detected to be significantly changed. The antifungal susceptibility testing of FLC and penicillin revealed their resistance pathways are merged. Accumulated mutations were found in 564 T2 and 225 T8 genes, including four highly mutated genes that are functionally related to the target of rapamycin complex (TOR). Our study provides abundant data towards genome-wide understanding of the molecular basis of FLC resistance in T. asahii.</div>
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	Serveur d'exploration sur la rapamycine et les champignons
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Integrated transcriptomic analysis of Trichosporon Asahii uncovers the core genes and pathways of fluconazole resistance.

Integrated transcriptomic analysis of Trichosporon Asahii uncovers the core genes and pathways of fluconazole resistance.

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